Injecting cortisone can sometimes relieve pain for anything from a sports injury to arthritis. Your healthcare provider may suggest an injection if rest, splints, physical therapy, rehabilitation exercises, or oral medicine doesn't relieve your pain. Injecting cortisone is simpler than having surgery. And cortisone may provide the lasting pain relief that can help you get out and enjoy life again. Be sure to discuss all choices with your healthcare provider. Injections are usually used no more than 3 to 4 times a year in 1 area of the body.